Skepinone-L
- Product Name
- Skepinone-L
- CAS No.
- 1221485-83-1
- Chemical Name
- Skepinone-L
- Synonyms
- CS-1010;CBS3830;SKEPINONE;Skepinone-L;Skepinone-L, >=98%;Skepinone-L (CBS3830);Skepinone-L USP/EP/BP;inhibit,SkepinoneL,Skepinone-L,CBS-3830,Skepinone L,CBS 3830,Autophagy,p38 MAPK,Inhibitor;(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann;3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
- CBNumber
- CB52628399
- Molecular Formula
- C24H21F2NO4
- Formula Weight
- 425.42
- MOL File
- 1221485-83-1.mol
Skepinone-L Property
- Melting point:
- 130-134°C
- Boiling point:
- 629.0±55.0 °C(Predicted)
- Density
- 1.384±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 13.49±0.20(Predicted)
- form
- Solid
- color
- Light Yellow to Yellow
Safety
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 16974
- Product name
- Skepinone-L
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 16974
- Product name
- Skepinone-L
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 16974
- Product name
- Skepinone-L
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $380
- Updated
- 2024/03/01
- Product number
- 16974
- Product name
- Skepinone-L
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $665
- Updated
- 2024/03/01
- Product number
- S499000
- Product name
- Skepinone-L
- Packaging
- 25mg
- Price
- $945
- Updated
- 2021/12/16
Skepinone-L Chemical Properties,Usage,Production
Description
Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC50 = 25 nM) or TNF-α in THP-1 cells. At 1 μM, it prevents phosphorylation of cytosolic phospholipase A2 in platelets in response to collagen-related peptide or thrombin , blunting platelet secretion and aggregation.
Uses
Skepinone-L is a potent and highly selective inhibitor of p38 MAP kinase which impairs platelet activation and thrombus formation.
target
p38-MAPK
References
[1]. koeberle, s c et al., skepinone-l is a selective p38 mitogen-activated protein kinase inhibitor. nature chemical biology, 2012, 8(2), 141-143.
Skepinone-L Preparation Products And Raw materials
Raw materials
Preparation Products
Skepinone-L Suppliers
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